Cover Feature: Total Synthesis of a Pentasaccharide O‐Glycan from <i>Acinetobacter baumannii</i> (Eur. J. Org. Chem. 16/2023)

Total synthesis of (±)-cortistatin J from furan.

A concise, diastereoselective total synthesis of (±)-cortistatin J has been completed in 20 steps from furan. Key steps include an intramolecular [4 + 3] cyclization of a disubstituted furan with a (Z)-2-(trialkylsilyloxy)-2-enal to construct the tetracyclic core and a (Z)-vinylsilane/iminium ion cyclization to form the A ring.

Total synthesis of Le(A)-LacNAc pentasaccharide as a ligand for Clostridium difficile toxin A.

The toxins TcdA and TcdB produced by the human pathogen Clostridium difficile gain entrance to host epithelial cells by recognizing cell-surface carbohydrate ligands. Inhibiting the attachment of these toxins to host cells has been proposed to be a viable therapy to treat C. difficile infections. Glycan array screening previously revealed that the Le(A)-LacNAc pentasaccharide binds strongly to ...

synthesis of sulfides from alcohols and thiols in solvent-freeconditions and deoxygenation of sulfoxides

کاتالیست یک سنتز جدید برای تیواترها توصیف شده است. واکنش الکل ها با آریل، هتروآریل و آلکیل تیو ل ها درحضور 1،3،5- تری آزو- 2،4،6- تری فسفرین-2،2،4،4،6،6 هگزاکلراید ((tapc به عنوان یک کاتالیست موُثر، بازده های خوب تا عالی از تیواترها را حاصل می کند. علاوه براین، واکنش تحت شرایط بدون فلز و بدون حلال پیش می رود، بنابراین یک مکمل جالب برای روش های شناخته شده سنتز تیواترها ارائه می دهد. یک مکانیسم ا...

Concise synthesis of a buffalo milk pentasaccharide derivative.

An efficient synthesis of buffalo milk pentasaccharide derivative via a 3+2 strategy is described. The use of a trisaccharide isopropyl thioglycoside as a latent glycosyl donor and the application of two well-defined regioselective glycosylations significantly simplified the target preparation.

Publisher's Note: "The total position-spread tensor: Spin partition" [J. Chem. Phys. 142, 094113 (2015)].